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KMID : 1377020220190040853
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Tissue Engineering and Regenerative Medicine
2022 Volume.19 No. 4 p.853 ~ p.860
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Selective Serotonin Reuptake Inhibitor Promotes Bone-Tendon Interface Healing in a Rotator Cuff Tear Rat Model
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Yoon Jong-Pil
Yoon Jee-Wook
Kim Hun-Min
Oh Joo-Han
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Abstract
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Background: Selective serotonin reuptake inhibitor (SSRI) is believed to accelerate wound healing, and thus expected to have a positive effect on rotator cuff repair. We hypothesized that SSRI has a positive effect on the healing of the bone-tendon interface (BTI), and improved rotator cuff tear healing would be confirmed by mechanical strength measurements and histological assessment of the restored tendon.
Methods: The study used 40 adult male Sprague?Dawley wild-type rats. The animals were divided into two groups: group-SSRI, the supraspinatus repair with SSRI injection group, and group-C, conventional supraspinatus repair only without SSRI. Biomechanical and histological analyses were performed 8 weeks after index rotator cuff surgery.
Results: The ultimate load (N) was significantly higher in group-SSRI than in group-C (54.8?±?56.9 Vs 25.1?±?11.1, p?=?.031). In the histological evaluation, the Bonar score confirmed significant differences in collagen fiber density (group-C: 0.6?±?0.5, group-SSRI: 1.1?±?0.6, p?=?.024), vascularity (group-C: 0.1?±?0.2, group-SSRI: 0.3?±?0.4, p?=?.024) and cellularity (group-C: 1.7?±?0.4, group-SSRI: 2.0?±?0.0, p?=?.023) between the groups. Based on the total score, group-SSRI was significantly better compared with group-C (6.3?±?2.7 Vs 4.3?±?1.9, p?=?.019).
Conclusion: Our study demonstrated that SSRI could facilitate improved biomechanical and histological outcomes 8 weeks after rotator cuff repair in a rat model. Consequently, SSRI may improve healing after rotator cuff repair.
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KEYWORD
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Serotonin uptake inhibitors, Anti-inflammatory agents, Histology, Biomechanics, Rotator cuff healing
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